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Indirect bilirubin is also usually increased in cholestasis due to the toxic effect of accumulated bile salts on hepatocytes or cholestasis-induced decreases in the hepatic transporters which take up unconjugated bilirubin from blood
The hyperglycemia that results from simultaneous inhibition of InsR signaling could be overcome through the design of more selective inhibition strategies, for instance inhibitors that target IGF-1R over InsR (perhaps through allosteric mechanisms)
However, after 48 h the larvae were granular in appearance, some markedly, irregular in shape, and movement was reduced