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Radiotherapy increases tumor cell ferroptosis susceptibility, significantly inducing the expression of long-chain acyl-CoA synthetase 4 (ACSL4) and the ferroptosis inhibitors SLC7A11 and GPX4, thereby effectively suppressing tumor growth (109)

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The incidence of 25(OH)VD deficiency/inadequacy is increasing due to the rise in metabolic syndromes such as insulin resistance (IR), obesity, and diabetes

These are typically brief side effects, making nasal sprays a much more comfortable option