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Patients should be counseled that scale weight may not accurately reflect body composition changes

From Rat Studies to Human Extrapolation From rat studies, the remarkably consistent effective dose range of 0.0045 mg/lb to 0.0000045 mg/lb intraperitoneally (a 1000-fold range showing similar efficacy) worked across depression, anxiety, Parkinsons, stroke, schizophrenia, and seizure models

Existing rebates and manufacturers' gaming risk may limit these gains

In their study, Yamada et al

You can make a good guess if a person is sleeping enough at night - observe how they act and function during the day