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The impact of TXNIP on ferroptosis seems to be manifold, as it downregulates SLC7A11 and GPX4 levels [108,122] , increases the labile iron pool via NCOA4-mediated ferritinophagy [123,124] , and disrupts GSH synthesis (Figure 3) [112]

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doi: 10.1074/jbc.M115.710582 75 LevyMTMcCaughanGWAbbottCAParkJECunninghamAMMllerEet al

Raising NAD + level stimulates short-chain dehydrogenase/reductase proteins to alleviate heart failure independent of mitochondrial protein deacetylation

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