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Pickart couldnt have predicted the gene expression data when he was watching liver cells in 1973

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A 2015 pilot crossover study (N=24) in healthy volunteers taking 1,200 mg/day ALA for 8 weeks found a statistically non-significant trend toward reduced free T3 (mean reduction 0.18 pg/mL, P = 0.08) without TSH elevation [4]

Detoxification & Immune Function NAD+ aids enzymes that clear out damaged cells and reduce oxidative stress

If you are deficient in these, even the best peptide protocol will struggle to build new collagen [1, 4]