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In contrast to phenobarbital, however, neither centrilobular hypertrophy nor proliferation of smooth endoplasmic reticulum was evident in the enlarged livers (Makino et al

PMID: 21584283

J Leukoc Biol 112(5):10651077 Li Y et al (2021) Dioscin ameliorates methotrexate-induced liver and kidney damages via adjusting miRNA-145-5p-mediated oxidative stress

Dosage recommendations vary by condition, usually ranging from 600 mg to 1400 mg per day , or sometimes more