The researchers used previously published Centers for Disease Control data of the concentrations of pulegone in select e-cigarette liquids -- and also in smokeless tobacco -- and combined these with the ingestion exposure data from animal studies to calculate a margin of exposure, a level used by regulatory agencies including the FDA to assess human health risks.Theoretically, the larger the safety margin, the safer the product
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View at Publisher | View at Google Scholar Mehta F S, Gupta P C, Bhonsle R B, Murti P R, Daftary D K, Pindborg J J
FDA Commissioner Robert Califf emphasized the long-term impact of the proposal, stating, "By the year 2100, this nicotine product standard could prevent approximately 48 million U.S
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Effective content should go beyond abstract health risks to include addiction, social acceptance, appearance, fitness, financial consequences, environmental harm, and religious values
