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doi:10.1001/jama.294.14.1799

In a 9-month monkey oral toxicity study, all female monkeys in the high-dose group showed minimal-to-slight periportal hepatocyte vacuolation

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Increased energy expenditure through enhanced NAD+ salvage pathway By inhibiting NNMT, 5-Amino-1MQ prevents the methylation and clearance of nicotinamide, channeling it back into the NAD+ salvage pathway and boosting cellular energy metabolism