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Always follow the dosage and frequency recommended by your healthcare provider
Understanding why refrigeration is necessary comes down to basic chemistry: proteins denature at higher temperatures
Like other copper-binding tripeptides, its biological effects are proposed to occur through both the peptide backbone and the copper ion it coordinates with the copper contributing to enzymatic cofactor activity and oxidative stress modulation
Indeed, after a decade or so, those who had been taking high-dose B6 supplements had about a 40 percent higher hip fracture risk, but not those taking B12
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