M., Zhang, W., Vatapalli, R., Calmon, M
Caffeine's ability to reduce inflammation is assumed to be a result of its ability to inhibit phosphodiesterase or to work against adenosine receptors (Lee et al., 2014
& Almaliki, M
The proteomic data showed that various antioxidant enzymes such as glutathione S-transferase theta 2 (GSTT2), glutathione S-transferase Mu 1 (GSTMI), and glutathione S-transferase alpha 1/2/5 (GSTA1/2/5) were upregulated in male mice livers treated with ibuprofen compared to controls (Fig
An inherent limitation of this study is that cell free extracts were used in enzyme activity assays which may possibly contain enzymes/proteins other than the glutamate dehydrogenases that could utilize NAD(P)H as co-factors and therefore confound GDH assay results
10.1016/s1570-0232(02)00618-9 J Chromatogr B Analyt Technol Biomed Life Sci