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Overall, the researchers found no association between donor smoking, pack-years of smoking or substance use and primary graft dysfunction at any time point

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This may be explained by the possible DNE and GOF effects of non-disruptive mutant p53 proteins that lead to increased proliferation, metastasis and chemo-resistance, whereas disruptive p53 mutations are unlikely to exert DNE and GOF effects [167]

Improved lung capacity

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