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In symptomatic B12 deficiency due to B12 malabsorption, parenteral administration of B12 is the default therapy

Furthermore, MT-II treatment in normal C57BL/6J mice did not significantly affect exploratory behavior in the open field test or repetitive behaviors as measured by the marble burying test

But here's the catch - NAD+ precursors like NR break down quickly in water and "degrade rapidly within weeks" [2]

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