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Clinical outcomes from the PARAMEDIC2 trial are summarized, showing higher rates of ROSC in the epinephrine group (36.3%) compared with placebo (11.7%), a modest increase in 30-day survival, but a higher proportion of survivors with severe neurological impairment (31.0% vs

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This implies a mechanistic link between smoke exposure mediated HBE cell necrosis and the chronic inflammation associated with airway remodeling

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