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it is a powerful modulator of gene expression

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This bypass also avoids first-pass metabolism, a process in which nutrients are partially broken down by the liver before they can be used

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Although we cannot rule out a contribution of glycolysis to this ATP increase and did not directly assess the activity of other complexes, we observed increased 5FU sensitivity with inhibitors of ETC complexes IIV, genetic ablation of CI and CIV, and sensitizer genes from CRISPR screening covering additional complexes (CIII and CV)