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As IC/BPS might be multifactorial, future research should target different implicated pathways simultaneously and study the role of reactive oxygen species as a root cause in IC/BPS

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Methods: SISTER (NCT05948566) is an ongoing, Phase 2, prospective, randomized, placebo-controlled, blinded, adaptive dose-finding clinical trial that aims to identify a dose of TS23 that is safe and potentially more efficacious than placebo

Eur J Pharmacol 2016

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Many denials are overturned when proper medical necessity is demonstrated, including imaging reports and records of failed conservative treatments