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4,5 A key advantage in the study of APAP toxicity is that its human pathophysiology can be effectively reproduced in a mouse model in vivo and in primary mouse hepatocytes
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Furthermore, sleep disorders in cirrhosis are closely related to HE, with overlapping mechanisms such as disrupted sleep patterns and hyperammonemia (37)
Intracellular acidification reduced gap junction coupling between immature rat neocortical pyramidal neurones
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It has not been extensively studied regarding safety for human consumption
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