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Since GSH is the final product of the homocysteine metabolism in the transsulfuration pathway by transferring sulfur from homocysteine to cysteine, a deficiency in transsulfuration pathway leads to excessive homocysteine production (hyperhomocysteinemia) and reduced GSH synthesis (159, 160)

S2CID 40084640

As per the experts, oral dosage o f glutathione is 250mg twice daily empty stomach for up to 4 weeks, topical route is 2% (w/w) applied once daily for nearly 2 months, and intravenous route is 1200mg injection given weekly over 30 minutes

Most effective consumer topicals fall between 1 and 2%

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