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Chemotherapy and radiation therapy can damage intestinal cells, leading to glutamine deficiency

A compound can be widely discussed and still rest almost entirely on cell-culture and animal data, with little or no controlled human evidence

Among 5 efficacy-evaluable mTNBC patients enrolled across multiple dose levels (48 mg/kg Q3W), the ORR was 80.0% (4/5 patients achieving partial response), with the remaining patient achieving stable disease accompanied by 29.5% tumor shrinkage

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