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COX-derived reactive species and transcriptional activity of interleukin-1beta ( IL-1 ), interleukin-6 ( IL-6 ), tumor necrosis factor- ( TNF- ), cyclooxygenase-2 ( COX-2 ), and inducible nitric oxide synthase ( iNOS ) are increased during aging (Michaud et al., 2013

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289 One limitation of ASNase therapy, which promotes tumor cell death by systematically lowering the asparagine concentration, is that it impairs ASN requirements in normal immune cells