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both NNMT and resveratrol modulate Sirtuin 1 (Sirt1) activity 83,84 , and resveratrol 83 and 5A-1MQ increase Parasutterella abundance, suggesting a potential causal link

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By selectively inhibiting NNMT, 5-amino-1MQ peptide preserves NAD+ availability, allowing cells to maintain optimal energy production and metabolic function

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