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Efficacy and safety of finasteride therapy for benign prostatic hyperplasia: results of a 2-year randomized controlled trial (the PROSPECT study)

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Additional ultrastructural changes may rarely include dilated granular endoplasmic reticulum, paracrystalline mitochondrial inclusions, and dilation of bile canaliculi, which is a result of impaired excretion of conjugated bilirubin and other organic anions from hepatocytes into the bile canaliculi

The two approaches answer different research questions and use different dosing conventions

This systems-level approach is increasingly common in modern regenerative biology research