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When the photosensitizers are ingested by tumor cells with high metabolic activity, ROS will be produced and cause tumor cell apoptosis, necrosis or autophagy after irradiation with an appropriate wavelength light source [195, 196]

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it can be transferred to the nucleus under oxidative stress to activate a variety of antioxidant enzymes, such as GPX (Zhang et al., 2018)

Kongtim P, Popat U, Jimenez A, Gaballa S, El Fakih R, Rondon G, Chen J, Bueso-Ramos C, Borthakur G , Pemmaraju N, Garcia-Manero G, Kantarjian H, Alousi A, Hosing C, Anderlini P, Khouri IF, Kebriaei P, Andersson BS, Oran B, Rezvani K, Marin D, Shpall EJ, Champlin RE, Ciurea SO

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