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Tirzepatide is the older, fully matured story: a single-molecule dual incretin agonist taken from discovery through Phase 1 proof-of-concept, [7] then through the large SURPASS (diabetes) and SURMOUNT (obesity) Phase 3 programs, and finally to FDA and EMA approval

Over-Dilution: Leads to a lower concentration than intended, which can result in inaccurate dosing

Hydroxocobalamin is preferred because it has a longer half-life and is retained in the body more effectively than cyanocobalamin (which is mainly available as oral supplements in the UK)

If we are treating autoimmunity or pernicious anemia, you will receive B12 weekly or twice weekly for 6-12 weeks

They have very different evidence bases and risk profiles