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Restoration of striatal dopamine levels, measured using HPLC, reached 4265.6 611.0 ng/g tissue in nanoparticle-treated mice compared to 2000.8 111.4 ng/g in MPTP control mice

The peptide appears to work by normalizing sleep architecture rather than acutely sedating, which explains the variable onset

The peptide works through non-hormonal mechanisms, does not suppress natural production of any substance, and shows no rebound effects upon discontinuation

Each line was initially differentiated to DE under the 4 conditions used in the initial EP screen, and after DE induction the cells were then differentiated to smHLCs 11