LOXs (EC 1.13.11.x) are non-heme iron, or sometimes manganese-dependent enzymes, that catalyze the regio- and enantioselective dioxygenation of polyunsaturated fatty acids (PUFAs) leading to the formation of fatty acid hydroperoxides (FAHPs) (Fig
Those details matter
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3D structures At the structural level, GSTs consist of an N-terminal domain adopting a thioredoxin fold and an all-helical C-terminal domain (Atkinson and Babbitt, 2009)
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