For example, conventional chondrogenic factors (Jonitz et al., 2012), epigenetic manipulation with specific agents (Duan et al., 2017), or co-culture with mesenchymal stem cells (Lai et al., 2013), have been shown to promote or maintain chondrocytic phenotype
Indeed, treatment of ECs with L-arginine increases production of both urea and NO, while treatment with L-valine, which inhibits arginase [IC 50 6.2 0.4 mM (Paik et al., 1978)], increases NO production only
E.MessinaA.Di MaioG.MondaV.MoscatelliF.et al (2024)
Recommended dosing of 1-2 mg subcutaneous injection 2-3x per week (6 mg/week total) compares to toxic dose estimated at ~22,500 mg (approximately 3,750 times higher than weekly dose)
(19, 20, 21, 26, 27) But its not easy for your body to make glutathione
Furthermore, BEC is a slow-binding inhibitor of arginase, which is still in the preclinical stage (Pudlo et al., 2017)