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While tirzepatide does not undergo significant renal clearance, limited safety data exist in severe kidney disease
In terms of efficacy, GH and IGF-1 both stimulated linear growth but some variables including the greater growth deficit in infants with Laron syndrome than those with isolated growth hormone deficiency, insufficient IGF-1 dose, or the IGF-1 dependency on the GH-linked stem cell population of prechondrocytes made GH more efficient in terms of linear growth stimulation (170, 171)
Bodi I, Mettke L, Michaelides K, Hornyik T, Meier S, Nimani S, et al
The goal is to help patients understand what may be contributing to slow recovery, what should be evaluated first, and what options are safest based on the whole health picture
The question of whether tirzepatide needs to be refrigerated comes up frequently