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Reported in 1991 by Damaschun et al., structural characterization of the acid unfolded apocytochrome c by DLS and SAXS (in combination with other biophysical approaches) likely represent one of the first applications of this approach for analysis of IDPs (Damaschun et al., 1991a)

4 In addition, genetic and epigenetic changes to DNA can affect the ability of sperm to fertilize an egg and create a viable embryo