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Description

Insulin-like growth factor (IGF)-binding protein-3 mutants that do not bind IGF-I or IGF-II stimulate apoptosis in human prostate cancer cells

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This nephroprotective effect is mediated by different mechanisms: reduced blood glucose levels, restoration of normal tubulo-glomerular feedback [160], reduction of glomerular hyperfiltration, increased lipolysis and weight loss [161], and suppression of inflammation and fibrosis [162, 163]

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Blankenberg S, Rupprecht HJ, Bickel C, Torzewski M, Hafner G, Tiret L, Lackner KJ

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