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According to Liu, B.s 2020 study, Maternal cigarette smoking before and during pregnancy and the risk of preterm birth: A dose-response analysis of 25 million mother-infant pairs, examining over 25 million mother-infant pairs, while the overall preterm birth rate was 9.3% (2,378,398 cases), smoking during just the first trimester significantly increased this risk

The Centers for Disease Control and Prevention reports that smoking any substance increases the risk of lung cancer, COPD, and heart disease

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