In preclinical models, ERR activation: Stimulates expression of genes associated with aerobic exercise adaptation Enhances mitochondrial biogenesis and oxidative respiration Increases fatty acid oxidation in skeletal and cardiac muscle Supports endurance capacity and metabolic flexibility Because of these effects, the compound has been described in the literature as an exercise mimetic a molecule that may reproduce certain biochemical signatures of physical training without the training stimulus itself
Xaa is a neutral aliphatic amino acid residue, in particular Ala, bAla, Leu, Ile, Gly, Val, Nle or the cation of the salt is an alkali metal or an alkaline earth metal, for instance Na + , K + , Li + , Cs + , Ca 2+ , or another metal, such as Zn 2+ , or a primary, secondary or tertiary amine or organic compound, such as NH 4 + , triethanolamine + , cyclohexylamine + , 2-AMP + (2-amino-1-propanol) or TRIS + (Tris-(hydroxymethyl)-aminomethan), as long as these cations are physiologically acceptable
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Rather than targeting appetite or hormones, MOTS-c primarily affects cellular metabolism
