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Mutations in ELAC2 associated with hypertrophic cardiomyopathy impair mitochondrial tRNA 3-end processing
Endometriosis may recur in up to 15% of women whether or not the patients are treated with estrogen therapy after bilateral oophorectomy (38)
Nevertheless, PS translocation to the outer leaflet of the phospholipid bilayer, a hallmark of eryptosis, can frequently occur without caspase-3 recruitment, primarily in response to Ca 2+ overload [84]
In mouse models, BHT promoted uterine fibroid formation by affecting P3K/Akt and MAPK signaling pathways, leading to increased proliferation and extracellular matrix accumulation [69]
Several endogenous metabolites, including ubiquinol, vitamin E, and vitamin K hydroquinone, function as radical-trapping antioxidants that terminate lipid peroxyl radicals and suppress ferroptotic membrane damage 84-87
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