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Pain typically worsens with movement and at night, often developing over 2-3 days from repetitive motions like overhead reaching, kneeling, or direct pressure lasting more than 30 minutes

Strain may be altered and relieved under thermal stress, inducing the loss of the stabilization effect

J Comput Assist Tomogr

Additionally, systemic side effects associated with sustained growth hormone stimulation include symptoms such as abnormal tissue growth, joint discomfort, and potential enlargement of the heart (cardiomegaly), Roberts says (21)