However, given that the calcium chelator activity of l-carnitine may induce cell damage and decrease serum calcium levels, the clinical benefits or improvements in in vitro fertility will not be achieved by the overuse of antioxidants at very high doses
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GPX1, 2, 3, 4 and 6 carry a highly reactive selenocysteine residue in their active site that is crucial for enzymatic activity and the efficient reduction of membrane hydroxy peroxides into their alcohol counterparts
However, these issues deserve further investigation in controlled, randomized and probably multicentre trials to evaluate the clinical value and the appropriate dosage of L-carnitine in each of these conditions