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Overdosage and underdosage relative to the prescribed dosageboth aspects of failure of adherencecan frequently be detected by concentration measurements when gross deviations from expected values are obtained

Multiple mechanisms have been studied and proven for vitamin A, including more than gene signaling pathways in terms of anticancer effects (70), the effect of retinoids on mitochondrial functions (71), and other mechanisms and pathways that have been studied and proven (72, 73)

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In 1999, a Swiss study based on data collected from the Cancer Registries of the Swiss Cantons of Vaud and Neuchtel investigated the risk of SPCs in prostate cancer survivors between 1974 and 1994

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