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The activation of mast cells caused the destruction of neighboring chondrocytes and the breakdown of cartilage.[ref] Related article: Osteoarthritis genes The figure below is from a study on mast cells in osteoarthritis (OA), showing both increased numbers of mast cells and an increase in tryptase

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For instance, one report proposed a model in which AIFM2 attenuates survival signaling in response to cytosolic foreign DNA, thereby contributing to apoptotic cell death 37,39