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Importantly, most of the above mentioned IF-mediated alterations in the eWAT immune compartment were absent in the HFD-IF-KO group, underscoring a major role for p53 in AT inflammation upon IF

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It is studied in preclinical models to investigate combined tissue repair strategies, synergistic effects on wound healing, musculoskeletal recovery, and gastrointestinal protection

10.3390/metabo7020014 14 Al-SayighM

According to Watanabe et al., the increase in the circulating BA levels after bariatric surgery might activate the thyroid hormonestimulated pathway involving TGR5 (or GPBAR1) and enhance thermogenesis and weight loss (126)