Conditions include alcoholic liver disease, viral hepatitis, cirrhosis, and primary or metastatic liver cancer Renal dysfunction : Impaired kidney function reduces B12 elimination, causing accumulation even with normal intake Haematological conditions : Myeloproliferative neoplasms, chronic myeloid leukaemia, polycythaemia vera, and hypereosinophilic syndrome increase transcobalamin production, elevating total serum B12 Laboratory interference : Macro-B12 (immunoglobulin-bound B12) and assay interference can cause spuriously elevated results without true excess In clinical practice, unexplained hypercobalaminaemia should prompt investigation for underlying disease, particularly in patients without obvious supplementation history
How is the dosing data sourced
Pharmaceutical intermediate synthesis
## **Other relevant codes** - **J3420** - Injection, vitamin B-12 cyanocobalamin, up to 1000 mcg - **J1270** - Injection, doxercalciferol, 1 mcg - **J0600** - Injection, edetate calcium disodium, up to 1000 mg Frequently asked questions
In diet-induced obese (DIO) mouse models, NNMT inhibition with 5-Amino-1MQ was associated with reduced white adipose tissue mass without affecting food intake, suggesting changes in energy expenditure rather than appetite suppression
Conventional medical doctors (MDs) routinely gave monthly B12 shots, especially to women patients, for vague symptoms from anxiety to fatigue
