[DOI] [PMC free article] [PubMed] [Google Scholar] 24.Eren S.H., Demirel Y., Ugurlu S., Korkmaz I., Aktas C., Gven F.M.K
(2018, September 13)
Platelet or vascular redox state, endogenous or exogenous antioxidants, and the production of reactive oxygen and nitrogen species are all potential factors in platelet-dependent thrombus development (156)
The downstream effects most consistently described in the literature: induction of collagen I and III, elastin, and decorin synthesis (Maquart et al., FEBS Letters , 1988), upregulation of VEGF and basic FGF transcripts, induction of antioxidant defense genes including SOD2 and metallothionein isoforms, and modulation of the MMP-2 and TIMP-1/2 balance toward non-fibrotic remodeling
It modulates over 4,000 human genes, upregulating collagen (COL1A1) and elastin while downregulating pro-inflammatory cytokines like TGF-1 and IL-6
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