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And oxidative stress may be one of the key drivers behind it

Effects of folic acid supplementation on cognitive impairment: A meta-analysis of randomized controlled trials

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Furthermore, oxido-neuroinflammation may be involved in the OMZ-instigated effect on reduced 5-HT metabolism

10.1186/s12943-018-0835-8 [DOI] [PMC free article] [PubMed] [Google Scholar] Fedoreyeva LI, Kireev II, Khavinson VK, Vanyushin BF (2011) Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA