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Chappell D, Hofmann-Kiefer K, Jacob M, Rehm M, Briegel J, Welsch U, Conzen P, Becker BF

LRP targeting peptidesAngiopep-2 LRP, including LRP-1 and LRP-2, is a ubiquitous endocytic cell membrane receptor that binds various ligands and controls the permeability of the BBB [96, 125]

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4.1 Study limitations and future directions First, the brain weight of HI-treated animals may be higher than that of controls due to cerebral edema occurring during and after the HI injury ( Ultimately, the understanding of systemic and brain PK of 7,8-DHF among neonatal mice could be applied to larger animal models of neonatal HIE especially the ones that show the kidney and liver injury phenotype that is not present in Vannuccis neonatal rodent model of HI

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