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This indicates that the concentration of acrolein produced by e-cigarettes significantly exceeds the normal level, posing a threat to human health

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Bergeron V, et al

On the contrary, early investigation had revealed that smokers with COPD (n=12) had less circulating CD8 + T cells and more chemokine receptor CXCR3 on CD8+ T cells than smokers without COPD (n=14) and nonsmokers (n=13), while smokers with and without COPD had more activated and cytotoxic (CD27-CD45RA+) CD8 + T cells in the peripheral blood than normal nonsmokers [59]