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Nature 618 , 144150 (2023)

Recent studies have identified new outcomes of hepatocellular injury, such as ferroptosis, a specific form of iron-dependent cell death that is closely associated with the pathogenesis of MASLD, given the livers propensity for iron metabolism and lipid peroxidation

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Although it is generally recognized that serum levels of unconjugated bilirubin must be elevated to cause neurotoxicity, the relationship between such elevations and brain injury is not simple