Nature 517 , 205208 (2015)
Recent research indicates that neuronal ATP and adenosine interact with their respective receptors-P2X and P2Y for ATP, and adenosine A 2A receptors (A 2A R) for adenosine-leading to pericyte contraction, which reduces CBF, or membrane hyperpolarization, which increases CBF [26, 87,88,89]
One acts on adipose tissue directly
Centella also carries a nice supporting cast of Vitamin A, vitamin C, several B vitamins, and amino acids
Evidence-Based Complementary and Alternative Medicine , 2018 , 4098942
NAC treatment significantly reduced kynurenine levels relative to placebo in vivo (raw p = 2.8 10 7 , FDR corrected p = 6.6 10 5 )