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In plasma, it is released through enzymatic degradation of larger proteins, particularly SPARC (secreted protein acidic and rich in cysteine, also called osteonectin) and collagen
Regulation of pulsatile growth hormone secretion by fasting in normal subjects and patients with acromegaly
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As a critical protein in the insulin signaling pathway, Akt activation is vital for normal insulin function: activated Akt regulates downstream targets to inhibit hepatic gluconeogenesis, promote cellular glucose uptake/utilization (maintaining blood glucose homeostasis), reduce hepatic glucose output via forkhead box O (FOXO) transcription factor inhibition, and enhance expression of genes like fatty acid synthase (FAS) to balance fatty acid synthesis and lipid metabolism
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Mrowicka, M., Mrowicki, J., Kucharska, E., & Majsterek, I
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