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First, during the Phase I , known as activation, specialized enzymesparticularly those of the cytochrome P450 familymodify the chemical structure of toxins to prepare them for Phase II

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Prev Med Rep

Caesar-TonThat, C

Treadmill running (10 m/min, 5 days/week for 6 weeks) increases dopamine D2 receptor-like binding in the dorsomedial caudate putamen, ventrolateral caudate putamen, ventromedial caudate putamen, and olfactory tubercle, supporting its potential antidepressant effects [106]