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Anitric oxide synthase transgene ameliorates muscular dystrophy in mdx mice

It stimulates the NRF-2 pathway by inhibiting its repressor KEAP1 and promoting NRF-2 nuclear translocation

At greater than or equal to 4 times the human clinical exposure based on AUC in patients with ITP at 75 mg/day and 2 times the human clinical exposure based on AUC in patients with chronic hepatitis C at 100 mg/day, cataracts were observed in mice after 13 weeks and in rats after 39 weeks of dosing [see Warnings and Precautions (5.5)]

A one- or two-week pause in weight loss is normal fluctuation, not a plateau

For chronic weight management, the same starting dose and titration schedule apply

This is one of the reasons why an empty vile of sterile water contains only a couple of milliliters of liquid