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Further demonstrating the therapeutic potential of targeting glycolysis, the natural compound derivative D5, sourced from Radix Aucklandiae, attenuates colitis in mice by impeding the nuclear translocation of PKM2 dimers, thereby suppressing glycolytic flux and Th17 cell differentiation (211)

Although homocysteine thiolactone has not been unequivocally identified in vivo , it might be a major by-product of deregulated homocysteine metabolism

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"Interactions of methylene blue with human disulfide reductases and their orthologues from Plasmodium falciparum"

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