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The majority of clinical evidence derives from substitutes for the oral cavity [109, 110, 114117, 122, 127, 128, 130, 134, 136, 139]
Originally discovered in human plasma, GHK-Cu plays a significant role in tissue repair, wound healing, collagen production, antioxidant defense, and skin regeneration
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Indeed, while efficiently inducing ferroptosis in different tumor cell lines, RSL3 and ML162 were found to also acts on TXRND1, an important detoxifying enzyme whose inhibition can also trigger apoptosis and/or ferroptosis [51, 52]