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Animal study design Adult female sheep (ewes) were used in all experiments because male sheep are naturally more aggressive and thus not amenable for long-term experimentation without the use of general anesthesia

FOR CIGARETTE AND PIPE USE 1

[71] This is applied in the most recently introduced models, which are activated by a pressure difference when the user inhales from the e-cigarette, avoiding pressing a button to heat the device

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It has gone on to note there is clear evidence that e-cigarettes are substantially less harmful than conventional cigarettes

Reported levels of low life satisfaction and low self-worth among smokers have also increased substantially